Dose and Route Related Effects of Mono Isoamyl 2, 3- Dimercaptosuccinic Acid in Male and Female Guinea Pigs

It is well known that different species have different resistance to the same compound. In the present study, an attempt was made to compare the dose dependent effects of mono isoamyl 2, 3dimercaptosuccinic acid (MiADMSA), a thiol metal chelating drug, through intraperitoneal administration in male and female guinea pigs. Effects of MiADMSA on various biochemical parameters suggestive of alterations in heme biosynthesis, hepatic, renal and brain biochemical variables after 21 days of repeated intraperitoneal administration to both male and female guinea pigs were studied. Essential metal concentrations in blood and soft tissues was also determined along with histopathological observations of hepatic and renal tissues. The results suggest no marked effect of MiADMSA on heme biosynthesis. However, moderate signs of hepatic lesions, based on specific biochemical indices supported by histopathological observations, were noted. There was a significant loss of copper and calcium following MiADMSA administration in both male and female guinea pigs. Interestingly, females showed more sensitivity/ susceptibility to MiADMSA compared to males.